关于阿片类药物不良反应与基因多态性之间的关联的研究:个案对照研究
Jing Yang1,2,3, Ying-Zi Sun3, Qun-Fang Li2
1School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
BMC pharmacology & toxicology
|November 22, 2023
概括
在ABCB1的基因变异与阿片类药物不良反应 (ADRs) 有关. 具有特定ABCB1基因型 (CT和TT) 的患者表现出较高的副作用发病率,特别是在使用氧化时.
科学领域:
- 药物基因组学 药物基因组学
- 临床药理学 临床药理学
- 在瘤学瘤学.
背景情况:
- 对阿片类药物反应和药物不良反应 (ADRs) 的个体变化是一个重要的临床挑战.
- 了解ADRs的遗传基础对于个性化疼痛管理至关重要.
研究的目的:
- 为了研究基因多态化与在接受阿片类药物治疗的患者中发生ADR之间的关联.
- 为了确定特定的遗传标记,预测发展ADRs的风险.
主要方法:
- 一项涉及120名癌症疼痛患者的病例对照研究 (60名有ADR,60名没有) 接受了阿片类药物 (吗啡,可代因, oxycodone) 的治疗.
- 目标基因 (CYP2D6*10,CYP3A5*3,ABCB1,OPRM1) 用聚合酶链反应 (PCR) 或现场杂交进行分析.
- 统计分析将遗传数据与年龄,性别和药物剂量等临床因素结合起来.
主要成果:
- 大多数目标基因在组之间没有发现基因型分布的显著差异.
- 然而,在ABCB1 (062rs1045642) 基因多态性方面观察到一个显著的关联.
- 患有ABCB1 (062rs1045642) 的CT和TT基因型的患者表现出较高的副作用发生率,特别是在用氧化治疗时.
结论:
- 在ABCB1基因 (062rs1045642) 中的多态性与氧化引起的ADR风险增加有关.
- ABCB1的T等位基因与较高的ADR发生率有关.
- 由于ABCB1基因多态化可能作为氧化诱导的ADRs的预测生物标志物,因此需要在CT和TT基因型患者中进行更密切的监测.
更多相关视频
09:54Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
Published on: March 8, 2020
5.3K
07:00A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
10.1K
相关概念视频
Opioid Receptors: Overview
916
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
916
Analgesia and Pain Management
632
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
632
Opioid Analgesics: Morphine and Other Natural Cogeners
259
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
259
Opioid Analgesics: Synthetic and Semisynthetic Opioids
307
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
307
Human Genetics
586
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
586
Single Nucleotide Polymorphisms-SNPs
15.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.2K
