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外围产痛和产后抑郁症之间的关联:一项随机对照试验

H S Tan^1,2, C W Tan^1,2, R Sultana³

¹Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore, Singapore.

|November 22, 2023

概括

外围产痛缓解并没有显著增加产后抑郁症的风险. 这项随机对照试验发现,在分娩期间接受外周止痛与非外周止痛治疗的妇女中,产后抑郁症的发生率相似.

科学领域:

产科和妇科产科和妇科
麻醉学麻醉学
精神病学是一个精神病学.

背景情况:

有矛盾的证据存在关于外周产痛和产后抑郁风险.
以前的观察性研究在控制混因素方面存在局限性.

研究的目的:

为了确定外周止痛是否与产后抑郁症发病率的显著变化有关.
用随机对照试验调查外围止痛和产后抑郁症之间的关联.

主要方法:

一项随机对照试验招募了881名年龄在21-50岁的单独怀孕的女性.
参与者被随机分配到外周止痛或非外周止痛.
产后抑郁症在分娩6-10周后使用爱丁堡产后抑郁症量表进行评估.

主要成果:

62 (15.9%) 的外围注射组女性和65 (16.9%) 的非外围注射组女性患有产后抑郁症.
在 epidural 和非 epidural 组之间没有观察到产后抑郁症发病率的显著差异 (调整后风险差异: 1.6%,p=0.49).
每项协议分析也得出了类似的非显著结果.

结论:

外周产痛并没有与产后抑郁症的显著增加风险有关.
这项随机对照试验提供了关于产后心理健康的外周止痛安全性的强有力的证据.

关键词:

结合的脊柱-表皮外科.劳动力镇痛劳动力镇痛劳动力镇痛产科产科产科产科产后抑郁症产后抑郁症

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