在精神分裂症患者的视听语言感知过程中异常的连接和激活
Yoji Hirano1,2,3, Itta Nakamura2, Shunsuke Tamura1,2
1Department of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
The European journal of neuroscience
|November 22, 2023
概括
精神分裂症患者由于异常的大脑连接而表现出受损的视听语言感知. 这项研究揭示了用于整合语音和面部线索的神经通路的削弱,这与社会沟通缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 有效的面对面沟通依赖于在语音感知过程中整合语音和面部线索.
- 以前的研究表明,精神分裂症患者在视听语音感知方面存在行为缺陷.
- 精神分裂症中这些缺陷的潜在神经生理机制尚不清楚.
研究的目的:
- 调查精神分裂症患者在视听语音感知过程中听觉皮层的神经活动和连接性.
- 为了比较精神分裂症患者和健康对照者之间的附加反应和功能连接.
主要方法:
- 磁脑电图 (MEG) 用于记录与事件相关的场.
- 对23名精神分裂症患者和22名健康对照人进行了听觉 (声音),视觉 (面部) 和视听 (面部声音) 刺激.
- 分析的重点是附加性反应和功能连接,特别是从侧面硫的左后.
主要成果:
- 健康对照对象在左半球表现出亚加的N1m效应 (视听响应<听觉和视觉响应的总和).
- 精神分裂症患者缺乏这种附加反应,表明视听一体化受损.
- 在精神分裂症患者中,从左侧听觉皮层到右侧状环的功能连接性较弱,与负面症状严重程度相关.
结论:
- 精神分裂症与语言和面部处理皮质区域之间的异常连接有关.
- 视听语音整合的缺陷,以异常的附加反应和弱化的连接性为特征,可能是精神分裂症社会沟通障碍的基础.
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