抗菌,抗氧化和可注射的水凝,使用CuS和黄素共载的菌构成,用于NIR增强的感染伤口愈合
Pengpeng Jia1,2, Yu Zou1,2, Jiang Jiang1,2
1School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China. yzou2012@sinano.ac.cn.
Journal of materials chemistry. B
|November 22, 2023
概括
这项研究开发了一种含有硫化铜纳米粒子和黄素的新型复合水凝. 水凝显示了增强的抗菌和抗氧化特性,改善了伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术 纳米技术
背景情况:
- 受感染的全厚皮肤伤口需要先进的治疗方法,结合抗菌和抗氧化特性.
- 开发功能性水凝对于有效的伤口管理和加速愈合至关重要.
研究的目的:
- 创建一种新的复合水凝 (CF-CuS-cur) 用于治疗受感染的皮肤伤口.
- 评估开发的水凝的抗菌,抗氧化和伤口愈合能力.
主要方法:
- 与CuS纳米颗粒和黄素联合封装成F127粒.
- 通过希夫基反应与碳氧甲基基托进行交叉链接,形成水凝.
- 在全厚皮肤伤口模型中评估水凝特性,体外疗效和体内伤口愈合.
主要成果:
- 该CF-CuS-cur水凝表现出适当的胀,降解,生物相容性和可注射性.
- 在近红外 (NIR) 辐射下表现出优异的光热抗菌活性和强大的抗氧化能力.
- 通过绝育加速伤口愈合,减少炎症,促进皮肤再生,原沉积和新血管化.
结论:
- 开发的水凝为创建具有NIR增强抗菌和抗氧化性能的功能性伤口带提供了一个简单的策略.
- CF-CuS-cur水凝显示出治疗慢性和感染伤口的巨大潜力.
- CuS,黄素和NIR辐射的协同效应有助于改善治疗结果.
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