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对2型糖尿病的重量为中心的治疗
Wissam Ghusn1, Maria Daniela Hurtado2, Andres Acosta1
1Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MNMayo Clinic, Rochester, MN, USA.
Obesity pillars
|November 22, 2023
概括
2型糖尿病 (T2DM) 药物在对体重的影响上有所不同. 一些T2DM药物会导致体重增加,而其他药物,如GLP-1激动剂和SGLT-2抑制剂,促进体重减轻,有助于T2DM管理.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 是一种普遍的慢性疾病,对健康和经济产生重大影响.
- 肥胖是T2DM的一个关键可修改的风险因素.
- 许多T2DM药物可以加剧肥胖症,从而造成具有挑战性的治疗周期.
研究的目的:
- 审查常见T2DM药物对患者体重的影响.
- 总结有关与T2DM药物治疗相关的体重变化的现有证据.
- 为以体重为中心的T2DM治疗策略提出专家建议.
主要方法:
- 在MEDLINE,谷歌学者,PubMed,Scopus和Embase (1950-2022) 的综合文献搜索.
- 专注于英语研究,评估T2DM药物及其对体重的影响.
- 对大多数处方T2DM药物的审查和它们与体重相关的结果的综合.
主要成果:
- 某些T2DM药物 (胰岛素,硫尿素, thiazolidinediones,巨胺) 与体重增加有关.
- 比瓜尼德 (甲胺),GLP-1激动剂 (赛马格卢提德,利拉格卢提德,蒂尔泽帕提德),SGLT-2抑制剂和氨酸类型促进减肥.
- DPP-4 抑制剂通常是体重中立的.
结论:
- 建议向体重中性或减肥T2DM药物进行范式转变.
- 优先考虑GLP-1激动剂,SGLT-2抑制剂和甲胺等药物可以通过解决肥胖症来改善T2DM管理.
- 采取以重量为中心的方法对于有效的T2DM治疗至关重要.
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