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儿童败血症幸存者对败血症引起的长期免疫功能障碍有抵抗力
David F Colón1,2, Carlos W Wanderley1,3, Walter M Turato1
1Center of Research in Inflammatory Diseases (CRID), University of São Paulo, Ribeirão Preto, Brazil.
British journal of pharmacology
|November 22, 2023
概括
年龄决定了对败血症的免疫反应. 儿童败血症幸存者表现出对二次感染的抵抗力,与成年人不同,原因是因特乐因-33 (IL-33) 水平较低和调节性T细胞 (Treg) 扩张.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科重症监护的儿童重症监护
- 传染病 传染病 传染病 是一种传染病.
背景情况:
- 败血症幸存者经常经历免疫抑制和二次感染.
- 轴IL-33/ILC2s/M2巨/Tregs介导成人败血症后免疫抑制.
- 儿科败血症的长期免疫效应尚不清楚.
研究的目的:
- 调查年龄在败血症引起的免疫抑制中的作用.
- 为了比较婴儿与成年后败血症小鼠的免疫反应.
- 评估成人和儿科败血症幸存者的临床差异.
主要方法:
- 调节性T细胞 (Treg) 频率和IL-33/ILC2s轴激活在后败血症婴儿和成年小鼠中的比较.
- 评估了后败血性小鼠肺上皮细胞中的DNA甲基化.
- 挑战性败血症幸存的小鼠与Pseudomonas aeruginosa和B16黑色素瘤.
- 在成人和儿科败血症幸存者的血液样本中测量IL-33水平和Treg频率.
主要成果:
- 两周大的小鼠对二次感染和瘤挑战具有抵抗力,与6周大的小鼠不同.
- 术后的6周大的小鼠显示IL-33,Tregs,ILC2s和M2巨细胞的增加;2周大的小鼠没有.
- 年轻小鼠中的IL-33产生受损与肺上皮细胞DNA甲基化相关.
- 给予IL-33诱导了年轻小鼠的免疫抑制.
- 成年败血症幸存者比儿科幸存者具有更高的IL-33和Tregs.
结论:
- 介素-33 (IL-33) 在败血症后的免疫抑制中起着关键的,年龄相关的作用.
- 年龄显著影响了败血症后免疫抑制的发展.
- 了解这些依赖年龄的机制可以为儿科和成人败血症的差异性治疗提供信息.
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