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脱细胞化细胞外基质在组织再生中的交联策略

Su Qiao¹, Tan Peijie¹, Jiang Nan¹

¹State Key Laboratory of Oral Diseases/National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Journal of biomedical materials research. Part A

|November 22, 2023

概括

脱细胞化细胞外基质 (dECM) 在再生医学方面表现有前途. 交叉连接增强了dECM生物材料,改善了组织和器官的再生.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
组织工程是组织工程.

背景情况:

脱细胞化细胞外基质 (dECM) 保留了原生组织特性,为再生医学提供生物相容性.
脱细胞化可能会损害dECM的结构完整性和机械强度.
交叉连接对于恢复和增强dECM的生物力学特性和生物活性至关重要.

研究的目的:

提供dECM生物材料的概述.
描述和比较dECM的交叉连接方法.
突出跨链dECM在组织和器官再生中的应用.

主要方法:

审查脱细胞化技术及其对dECM的影响.
对dECM的物理和化学交联机制的分析.
检查dECM在各种组织 (皮肤,心脏,血管,肝脏,脏) 的应用.

主要成果:

交叉连接有效地恢复和改善dECM的机械强度,稳定性和生物活性.
量身定制的交叉连接策略可以平衡生物材料降解与宿主组织再生.
基于dECM的生物材料显示出在再生各种组织和器官方面的潜力.

结论:

交叉连接是优化dECM生物材料在组织工程中的关键步骤.
多功能dECM应用可以通过适当的交叉连接修改来实现.
对交叉连接方法的进一步研究将促进再生医学战略的发展.

关键词:

交叉连接试剂的试剂.脱细胞化的细胞外矩阵.再生医学是一种再生医学.组织工程是组织工程.

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