通过骨髓介质干细胞植入完整脊髓损伤患者的神经功能改善:一个病例报告
Ying-Chuan Kuan1,2, Shinn-Zong Lin1,2,3, Tsung-Lang Chiu1,2
1Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, 970, Taiwan.
Regenerative medicine
|November 22, 2023
概括
骨髓介质干细胞 (BMSC) 疗法在慢性脊髓损伤 (SCI) 中显示出潜在的安全性和有效性. 这项案例研究观察到,在完全SCI的患者身上,自主BMSC移植后,感觉和生活质量得到改善.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 细胞疗法细胞疗法
背景情况:
- 脊髓损伤 (SCI) 会导致严重的残疾.
- 基于干细胞的疗法正在进行SCI治疗的研究.
- 慢性阶段的SCI对恢复提出了独特的挑战.
研究的目的:
- 报告在患有慢性完全SCI的患者中使用自身骨髓介质干细胞 (BMSCs) 的经验.
- 评估BMSC治疗在这个患者群体中的安全性和潜在疗效.
主要方法:
- 一名25岁的男性患有T6完全SCI和5年,接受了骨髓内自主BMSC移植.
- 该患者经历了12个月的随访期.
主要成果:
- 巴特尔指数得分显著改善,从严重的依赖过渡到中度的依赖.
- 报告了增强的感觉水平,从T7改善到S5.
- 移植后没有观察到运动功能的改善.
结论:
- 自体BMSC似乎是慢性完整SCI的潜在安全的治疗选择.
- BMSC治疗可能有助于改善SCI患者的神经功能和生活质量.
- 需要进一步的研究来探索BMSC在SCI治疗中的全部潜力.
更多相关视频
10:03Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model
Published on: November 21, 2019
7.7K
09:14Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
Published on: April 5, 2016
9.0K
相关概念视频
Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
