在两个小鼠线下,在出生体重环境变异的不同选择下,两种小鼠线的同卵性运行中的差异性模式
Candela Ojeda-Marín1, Juan Pablo Gutiérrez1, Nora Formoso-Rafferty2
1Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
概括
运行同卵性 (ROH) 分析揭示了因出生体重而被分离选择的小鼠系中的基因组内生育模式. 虽然整体内生没有差异,但特定的染色体区域显示出明显的ROH分布,这可能解释了强度的差异.
科学领域:
- 基因组学就是基因组学.
- 动物育种 动物育种
- 量化遗传学 量化遗传学
背景情况:
- 同胞性运行 (ROH) 表明基因组区域从共同祖先中继承.
- 已经实现了对小鼠出生体重变异的分离选择,与强度相关的低变异性.
- 了解基因组内生模式对于动物繁殖和遗传研究至关重要.
研究的目的:
- 为了分析同卵性 (ROH) 模式的运行和基于ROH的基因组近亲繁殖,在分离选择的小鼠系中分析出生体重变化.
- 为了比较来自血统和ROH方法的内生系数.
- 为了研究在选定的小鼠线中ROH分布和强度之间的关系.
主要方法:
- 使用高密度小鼠基因型阵列,从高可变性线 (H线) 选取752个个体,从低可变性线 (L线) 选取766个个体.
- 使用滑动窗 (SW) 和连续运行 (CR) 方法识别ROH.
- 亲生生殖系数的计算:基于血统 (FPED),基于ROH-SW (FROHSW) 和基于ROH-CR (FROHCR).
主要成果:
- 基于血统的近亲繁殖 (FPED) 和基于ROH的近亲繁殖 (FROH) 之间的相关性很高,特别是在FROHSW.
- 跨世代或在选定的线条之间没有观察到整体基因组内生育的一致差异.
- 在染色体水平 (染色体3,4,6,8,11,15,19) 之间发现了ROH估计的显著差异.
- 在ROH估计中,较长的同卵性细分显示出与FPED的相关性更高.
结论:
- 基于ROH的近亲繁殖估计,特别是那些使用较长的同卵性细分的近亲繁殖估计,与基于血统的近亲繁殖有很好的相关性.
- 选择的小鼠线之间的强度差异不仅仅是由于低可变性线的整体同胞性更高.
- 在特定的染色体中ROH的独特分布可能有助于观察到的强度差异,突出潜在的基因组区域用于未来的研究.
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