在中国大城市的移民中对结核病控制的影响:深的一项基于人口的潜在基因组流行病学研究
Peierdun Mijiti1,2, Changwei Liu3, Chuangyue Hong4
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, People's Republic of China.
Emerging microbes & infections
|November 22, 2023
概括
在深,内部移民推动了结核病 (TB) 的传播. 战略必须专注于在这个流动人口中诊断和治疗结核病,以改善中国城市的结核病控制.
科学领域:
- 基因组流行病学基因组流行病学
- 公共卫生 公共卫生
- 传染病控制 传染病控制
背景情况:
- 国内移民在城市环境中对结核病 (TB) 控制构成重大挑战.
- 了解移民中的结核病流行病学对于中国大城市有效的预防和控制战略至关重要.
研究的目的:
- 在深的内部移民中调查结核病的基因组流行病学.
- 确定与移民中的结核病传播集群相关的风险因素.
- 在已识别的基因组集群中推断传输动态和时间.
主要方法:
- 在深培养阳性结核病患者的前性基因组流行病学研究 (2018年6月 - 2021年5月).
- 隔离序列和基因组聚类 (≤12个SNP).
- 多变量分析,贝叶斯模型和TransPhylo用于传输推理.
主要成果:
- 70.1%的结核病患者是国内移民;许多人在抵达后不久就患上了结核病.
- 15.4%的菌株形成了基因组集群,传播与当地未接受治疗的移民有关.
- 没有在深接受治疗的移民,男性和教师/培训师与聚类有关.
结论:
- 深的结核病主要是由内部移民中感染的重新激活驱动的.
- 一部分移民可能已经抵达了先前存在的或初始的结核病.
- 针对内部移民的全面诊断和治疗策略对于深的结核病控制至关重要.
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