响应pH的多功能纳米平台,具有反应性氧物种控制的二氧化碳释放,用于增强型瘤治疗
Pinghua Ling1, Pei Yang1, Qiang Zhang2
1Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China.
ACS applied bio materials
|November 22, 2023
概括
一个新的多功能纳米平台通过将光动力疗法与化疗和一氧化碳释放相结合来增强瘤治疗. 这种方法改善了瘤吸收和细胞毒剂生成,以有效治疗癌症,并减少副作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 纳米材料对瘤治疗具有前景,但在瘤吸收和细胞毒剂生成方面面临挑战.
- 由于这些局限性,现有疗法在体内有效性往往有限.
研究的目的:
- 开发一个用于增强瘤治疗的多功能纳米平台.
- 克服目前基于纳米材料的癌症治疗中瘤吸收不良和细胞毒剂生成不足的局限性.
主要方法:
- 构建一个响应pH的纳米平台 (IL@CPPor(CO)) 集成过氧化铜纳米颗粒 (CPNP),一氧化碳 (CO) 捐赠剂,一个光敏剂 (IrPor) 和离子液体 (IL).
- 在酸性条件下利用CPNP的H2O2和Cu2+释放,触发Fe3(CO) 的CO释放12.
- 利用Cu2+进行谷氨耗尽和芬顿类反应,并利用IrPor进行过氧化酶类活性和光敏化,以产生活性氧物种 (ROS).
主要成果:
- 该纳米平台证明了pH取决于ROS的产生,从而有效释放CO.
- CO和ROS的联合作用促进了癌细胞的亡,并提高了治疗效果.
- 该纳米平台表现出高瘤积累,低毒性,以及良好的生物相容性 in vivo.
- 观察到有效的瘤生长抑制与最小的副作用.
结论:
- 开发的多功能纳米平台有效地结合了光动力疗法,化疗和CO释放能力.
- 这种综合方法通过解决当前纳米疗法的关键局限性,显著提高了抗瘤疗效.
- 该研究提出了先进瘤治疗的有希望的策略,提高了安全性和有效性.
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