使用设计质量开发Bimatoprost装载的脂质纳米配方:脂质体与固体脂质纳米颗粒在眼内压力降低中的比较
Piyush Verma1, Rishi Kumar Singh1, Anubhav Wadhwa1
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS (Deemed to be University), Mumbai, 400056, India.
Nanomedicine (London, England)
|November 22, 2023
概括
新的脂质体和固体脂质纳米粒子眼滴改善了青光眼的治疗. 这些配方被封装在热敏水凝中,提供持续的比马托普罗斯特释放,有效降低眼内压力.
科学领域:
- 眼科医生 眼科 眼科
- 纳米技术纳米技术
- 药品制造 药品制造 药品制造
背景情况:
- 青光眼的治疗包括使用比马托普罗斯特降低眼内压力.
- 传统的眼滴面临着诸如频繁剂量和由于眼洗而导致药物的生物利用性差等挑战.
研究的目的:
- 开发用于比马托普罗斯特的先进药物输送系统,以克服传统眼滴的局限性.
- 为了制定和评估脂质体和固体脂质纳米颗粒封装在热敏的in situ水凝中,用于增强青光眼治疗.
主要方法:
- 通过设计的质量方法被用来制定脂质体和固体脂质纳米粒子.
- 然后将这些纳米粒子封装在热敏的现场水凝中,用于眼部药物输送.
主要成果:
- 优化的脂质体显示了87.04%的封装效率和306.78nm颗粒大小.
- 固体脂质纳米粒子实现了90.51%的封装效率和304.21nm颗粒大小.
- 带有比马托普罗斯特的脂质体表现出受控的零顺序释放动力学,没有最初的爆发释放,表现优于固体脂质纳米颗粒.
结论:
- 在热敏水凝中装载着比马托普罗斯特的脂质体显示了持续的药物释放.
- 这种新的配方有效地降低了眼内压力长达18小时,表明改善了眼管理潜力.
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