与结合组织疾病相关的间歇性肺病中的渐进性肺纤维化因素
Kyuhwan Kim1, Jongmin Lee1, Yong Suk Jo2
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Therapeutic advances in respiratory disease
|November 22, 2023
概括
大约四分之一的结缔组织疾病相关的间歇性肺病 (CTD-ILD) 患者患有渐进性肺纤维化 (PPF). 免疫调节剂显著降低了这些患者患PPF的风险.
科学领域:
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
- 纤维化肺部疾病 纤维化肺部疾病
背景情况:
- 结合组织疾病 (CTD) 中的渐进性纤维化与结合组织疾病 (CTD) 相关的间歇性肺病 (ILD) 恶化患者的预后.
- 识别导致渐进性肺纤维化 (PPF) 的因素对于管理CTD-ILD至关重要.
研究的目的:
- 在CTD-ILD.患者中调查与渐进性肺纤维化 (PPF) 现型相关的因素.
- 在韩国一组CTD-ILD患者中确定PPF的发病率.
主要方法:
- 对被诊断患有CTD和ILD的患者的医疗记录的回顾性审查.
- 分析包括了超过一年的肺功能随访患者.
- 强迫生命能力 (FVC) ≥10%或一氧化碳 (DLco) ≥15%的扩散能力下降是PPF的定义.
主要成果:
- 24.5%的CTD-ILD患者进展到PPF.
- 类风湿性关节炎和肖格伦病是PPF患者中最常见的CTD类型.
- 使用全身类固醇或免疫调节剂与较低的PPF风险相关 (aOR:0.25).
结论:
- 大约四分之一的CTD-ILD患者患有PPF.
- 免疫调节剂表明对PPF发育有保护作用.
- 需要早期检测和量身定制的治疗策略,以改善患有PPF风险的CTD-ILD患者的治疗结果.
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