在日常数字测试的认知不受损的老年人中早期检测粉样蛋白相关的记忆变化
Kathryn V Papp1,2, Roos J Jutten2, Daniel Soberanes2
1Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Annals of neurology
|November 22, 2023
概括
在几天内评估日常学习可以检测早期阿尔茨海默病 (AD) 记忆变化,甚至在标准认知测试显示差异之前. 这种方法揭示了具有高β-粉样蛋白 (Aβ+) 个体的记忆巩固缺陷.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 认知健康 认知健康
背景情况:
- 阿尔茨海默病 (AD) 诊断通常依赖于只有在晚期阶段才能检测到的认知衰退.
- 早期发现AD相关的记忆变化对于及时干预至关重要.
- 标准的认知评估可能无法捕捉微妙的,早期的记忆巩固缺陷.
研究的目的:
- 调查是否在多天内评估学习可以揭示与阿尔茨海默病 (AD) 生物标志物相关的记忆巩固下降.
- 为了确定这些下降是否比单个时间点评估更早地检测到.
- 评估远程多日认知评估对临床前AD检测的有用性.
主要方法:
- 评估了36名具有高β-粉样蛋白 (Aβ+) 的个人和128名没有 (Aβ-) 的个人.
- 参与者在个人设备上使用神经认知健康的波士顿远程评估 (BRANCH) 每天使用12分钟,持续数天.
- 通过重复测试,BRANCH评估了每天的学习轨迹;参与者还接受了标准认知测试 (PACC-5).
主要成果:
- 在基线认知测试或初始学习中,Aβ+和Aβ-组之间没有发现显著差异.
- 与Aβ-参与者相比,Aβ+参与者在多天的BRANCH评估中显示了7天学习曲线的减少.
- 这些减少的学习曲线与临床前阿尔茨海默氏症认知复合体 (PACC-5) 的较大年度下降相关.
结论:
- 在几天内评估学习有效地揭示了在临床前阿尔茨海默病 (AD) 中与β-粉样蛋白 (Aβ) 相关的非常早期的记忆巩固缺陷.
- 这些微妙的记忆巩固失败可能先于传统的amnestic缺陷.
- 重复的数字记忆评估为检测临床前AD最早的认知变化提供了一种变革性的方法.
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