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Updated: Jul 10, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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含有环醇组的1,4-二胺和它们的结构类似物表现出既具有RyR2稳定性,又具有SERCA2a刺激性的活性

Gyuzel Y Mitronova1,2, Christine Quentin1, Vladimir N Belov1

  • 1Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, Göttingen 37077, Germany.

Journal of medicinal chemistry
|November 22, 2023
PubMed
概括

开发了新的化合物来治疗心血管疾病,通过稳定氨酸受体2 (RyR2) 和通过SERCA2a激活增强心脏水平,为心力衰竭治疗提供了潜力.

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