在低喉皮状细胞癌中同步肺转移的危险因素
Yujiao Li1,2,3,4,5, Chaosu Hu1,2,3,4,5
1Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Cancer Hospital, Shanghai, China.
Ear, nose, & throat journal
|November 22, 2023
概括
白人种族,较低的瘤阶段 (T) 和较高的瘤分化与低喉皮状细胞癌 (HPSCC) 中同步肺转移的风险降低有关. 晚期疾病和缺乏手术对生存率产生负面影响.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 流行病学 流行病学
背景情况:
- 低喉皮状细胞癌 (HPSCC) 是一个具有挑战性的诊断.
- 了解同步肺转移 (LM) 的风险因素对于患者的治疗结果至关重要.
研究的目的:
- 在被诊断为下喉平细胞癌 (HPSCC) 的患者中,确定与同步肺转移 (LM) 相关的风险因素.
- 分析HPSCC患者生存率的预测因素.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库 (2010-2013) 的数据.
- 采用了千二测试来检查风险因素和同步LM之间的关联.
- 进行单变量和多变量分析以评估生存预测因素.
主要成果:
- 分析了1683名HPSCC患者;4.2%的人有同步的LM.
- 白人种族,较低的T或N分类,以及高度差异化的瘤显著降低了LM风险 (P < .05).
- 老年,未婚的患者有高级的T / N分类,多种转移,没有初级瘤手术减少了预期寿命.
结论:
- 白人种族,较低的T/N分类和高瘤分化与HPSCC中同步LM风险降低相关.
- 晚期疾病阶段,缺乏手术干预和多个转移部位与较差的生存率有关.
- 强调需要量身定制的诊断和治疗策略,特别是在非高加索地区的患者中,先进的,差异化不良的HPSCC.
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