周边感觉神经的自发活动:系统性审查
Dongchan Choi1, George Goodwin1, Edward B Stevens2
1Wolfson Centre for Age-Related Diseases, Guy's Campus, King's College London, London, United Kingdom.
Pain
|November 22, 2023
概括
感觉神经元的自发活动有助于慢性神经病痛. 这次审查证实了它在人类和动物中长期存在,但强调了变异性和需要更多的受控研究.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 电子生理学 电子生理学
背景情况:
- 外围感官神经元的自发活动是慢性疼痛的关键驱动因素.
- 神经元敏感化是导致慢性疼痛的另一个主要原因.
- 神经病痛中自发活动的确切特征和时间概况尚不清楚.
研究的目的:
- 系统地审查和提取神经病痛时感官神经元自发活动的数据.
- 为了确定哪些感觉神经纤维类型表现出自发活动.
- 在临床前模型和人类实验对象中确定自发活动的时间进程.
主要方法:
- 系统的文献搜索和电生理学研究的数据提取.
- 从临床前的神经病痛疼痛模型的体内记录的分析.
- 对神经病痛患者微神经图记录的审查.
主要成果:
- 在神经性疼痛条件中存在自发活动的存在上存在广泛的共识,在动物和人类中持续数月和数年.
- 电生理学方法在量化自发活动时显示出很高的变化和不确定性.
- 人类和动物研究之间存在有限的直接控制实验和数据可比性.
结论:
- 自发的外围神经元活动是慢性神经病痛的一个记录良好的特征.
- 人类和动物数据之间显著的变化和缺乏直接可比性需要进一步的研究.
- 建议进行额外的受控实验,以更好地了解慢性疼痛的这一关键机制特征.
相关概念视频
Peripheral Nervous System: Ganglia and Nerves
2.0K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
2.0K
Somatic Spinal Reflexes
2.1K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
2.1K
Action Potential
8.0K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
8.0K


