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确定老年猫的精选血清和尿液生物标志物的特定年龄基准区间

Femke Mortier¹, Robby van Leeuwenberg¹, Sylvie Daminet¹

¹Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Oost-Vlaanderen, Belgium.

Journal of feline medicine and surgery

|November 22, 2023

概括

老猫的年度健康查需要特定年龄的参考间隔 (RIs) 来准确诊断脏疾病和甲状腺功能障碍. 对于成熟和老年猫类生物标志物,如肌素和甲状腺素,已建立了新的RI,改善了健康监测.

科学领域:

兽医医学兽医医学兽医医学
临床病理学临床病理学
老年动物卫生老年动物卫生

背景情况:

每年进行健康查对于早期发现老猫的疾病至关重要.
对脏和甲状腺参数缺乏年龄特定的参考间隔 (RIs) 阻碍了准确的诊断.
慢性病 (CKD) 和甲状腺功能障碍等疾病在老猫中很常见.

研究的目的:

为老年猫的关键脏和甲状腺生物标志物建立特定年龄的参考间隔 (RIs).
为了确定血清肌素 (sCr),对称二甲基氨酸 (SDMA),酸盐 (P),总 (tCa),总甲状腺素 (TT4),尿蛋白:肌素比率 (UPC) 和尿液特异性重量 (USG) 的RI.
为成熟成年 (7-10岁) 和老年 (>10岁) 猫提供不同的RI.

主要方法:

一项前性研究,涉及206只7岁及以上的健康客户猫.
猫进行了彻底的查,以排除系统性疾病.
根据美国兽医临床病理学学会的指导方针确定特定年龄的RI,并与现有的实验室RI进行比较.

主要成果:

在特定年龄的RI和现有的实验室RI之间观察到临床上显著的差异.
对于sCr,TT4和P的上限较低,而SDMA的上限在老猫中较一般实验室RI高.
对USG的下限较低,tCa和UPC的差异很小.

结论:

对脏和甲状腺生物标志物的年龄特定RI对于成熟成年和老年猫的精确健康查至关重要.
实施这些量身定制的RI对解释健康查结果具有重大临床影响.
为了改善兽医诊断,实验室RI的适应特定的猫种群是必要的.

关键词:

一个成熟的成年人.老年人的医疗服务进行健康查.脏脏脏是什么?高级高级高级高级高级高级高级高级高级高级甲状腺是什么?甲状腺是什么?

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