相关实验视频

Updated: Jul 10, 2025

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

为儿科急性淋巴细胞白血病进行全源性造血干细胞移植

Jieyu Tian¹, Ang Wei¹, Bin Wang¹

¹Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Annals of hematology

|November 22, 2023

概括

全基性造血干细胞移植 (allo-HSCT) 在儿科急性淋巴细胞白血病 (ALL) 中显示出有前途的结果. 生存率令人鼓舞,MLL基因融合表明这些年轻患者的预后更好.

科学领域:

儿科血液学瘤学儿科血液学
干细胞移植干细胞移植
白血病研究研究白血病研究

背景情况:

急性淋巴细胞白血病 (ALL) 仍然是儿科瘤学的一个重大挑战.
全基性造血干细胞移植 (allo-HSCT) 是高风险ALL的潜在治疗选择.
了解alo-HSCT对儿童的长期结果对于治疗优化至关重要.

研究的目的:

评估诊断为ALL的儿科患者allo-HSCT的预后.
评估关键的生存指标,包括总生存率 (OS) 和无事件生存率 (EFS).
确定影响该患者队列结果的预后因素.

主要方法:

采用了一个追溯案例系列设计.
分析了从75名儿科ALL患者获得的数据,这些患者在2009-2019年间接受了allo-HSCT.
评估了包括5年OS,EFS,复发率和移植与宿主疾病 (GvHD) 在内的结果.

主要成果:

五年总生存率 (OS) 和无事件生存率 (EFS) 分别为67.77%和57.30%.
五年复发率为35.69%. 在5年内,复发率为35.69%.
患有MLL基因融合的儿童的生存率更高;哈普罗-HSCT与HLA匹配移植相比较.

结论:

艾洛-HSCT为儿科ALL提供了可行的治疗选择,可接受的生存率.
虽然MLL基因重组与良好的结果有关,但复发和并发症需要监测.
哈普洛-HSCT是一种安全有效的替代HLA匹配的兄弟移植.

关键词:

急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.全基性造血干细胞移植造血干细胞移植移植对宿主疾病 (GVHD) 是一种移植对宿主疾病.预测预后预测预测复发复发的情况

更多相关视频

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...