在怀孕早期,IPV和心理健康症状对HPA轴功能的影响
Alytia A Levendosky1, Cecilia Martinez-Torteya2, Alexandra L Ballinger3
1Department of Psychology, Michigan State University, East Lansing, MI, 48824, USA. levendo1@msu.edu.
Archives of women's mental health
|November 22, 2023
概括
怀孕期间的亲密伴侣暴力 (IPV) 影响母亲的应激反应 (皮质醇反应性). 影响取决于抑郁和创伤后应激症状 (PTSS) 的严重程度,导致各种HPA轴失调.
科学领域:
- 生殖健康 生殖健康
- 神经内分泌学神经内分泌学
- 心理创伤学 心理创伤学
背景情况:
- 在怀孕早期,母亲的HPA轴调节失调可能会损害功能.
- 亲密伴侣暴力 (IPV) 是一个常见的压力因素,但它在怀孕期间对母亲HPA轴的影响不一致.
- 在孕妇人群中,IPV和心理健康症状对皮质醇调节的相互作用尚未得到充分研究.
研究的目的:
- 调查IPV,抑郁症状和创伤后应激症状 (PTSS) 在怀孕早期对母亲HPA轴的影响.
- 检查IPV和心理健康症状对皮质醇反应性的相互作用影响.
主要方法:
- 255名怀孕妇女,过量采样IPV,在15-18周怀孕时接受了实验室压力测试 (Trier社会压力测试).
- 压力后收集唾液样本,并对皮质醇进行分析.
- 用曲线下的面积与地面相比 (AUCg) 来测量皮质醇反应性. 抑郁症和PTSS使用经过验证的措施进行评估.
主要成果:
- 发现IPV,抑郁症状和PTSS对皮质醇AUCg之间存在显著的相互作用影响;主要影响并不显著.
- 在低抑郁症状时,IPV与阴性皮质醇反应相关,在中度水平没有显著的反应,在高水平的积极反应.
- 只有在高水平的PTSS时,IPV与阳性皮质醇反应性有关;在较低水平的PTSS时,影响无意义.
结论:
- 怀孕早期的孕产妇IPV与改变的HPA轴应激反应性 (过度活跃和变质) 有关.
- HPA轴失调的具体模式取决于抑郁症和PTSS的同时发生和严重程度.
- 这些发现突出了对母亲福祉和后代发育的潜在差异性影响.
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