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Biological Effects of Radiation02:59

Biological Effects of Radiation

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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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The Ratio of X Chromosome to Autosomes02:45

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In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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辐射研究中的性别差异

Lanyn P Taliaferro1, Rajeev K Agarwal2, C Norman Coleman3

  • 1Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Radiation and Nuclear Countermeasures Program (RNCP), Rockville, MD, USA.

International journal of radiation biology
|November 22, 2023
PubMed
概括

性差异在辐射研究中至关重要,影响医学对策和公共卫生. 未来的研究必须包括两性,以确保对所有人的准确和可复制的结果.

关键词:
女性的健康 妇女的健康生物测量仪生物测量仪医疗对策 医疗对策辐射辐射辐射辐射的辐射性别差异的性别差异.

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科学领域:

  • 辐射研究的研究.
  • 生物医学科学中的性别差异
  • 放射学和核应用.

背景情况:

  • 性是辐射研究中未被认可的混因素.
  • 在基本和转化性研究中了解性别特异性影响方面存在知识差距.
  • 对放射学和核应用的影响需要进一步研究.

研究的目的:

  • 解决性作为辐射研究中混者的角色.
  • 检查辐射动物模型中的性别差异及其对医学对策开发的影响.
  • 讨论生物对称,生物标志物,研究代表,监管政策和人类健康场景.

主要方法:

  • 与整个HHS的合作伙伴和利益相关者进行了一次研讨会.
  • 讨论包括学术研究人员,行业研究人员和美国政府代表.
  • 研讨会的重点是关于研究中的性别的科学影响和知识差距.

主要成果:

  • 当前的研究设计往往缺乏分析性别差异的统计能力.
  • 导致辐射反应性别差异的潜在因素在很大程度上是未知的.
  • 确定了监管政策和药物/设备开发方面的差距.

结论:

  • 研究人员必须在所有研究阶段都包括两性.
  • 适应性别差异可以确保强大,可复制和准确的结果.
  • 解决性别差异对于在放射和核环境中推进公共卫生至关重要.