相关实验视频
Updated: Jul 10, 2025

05:51
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
1.8K
生物医学应用的分子工程室温光:从可见光向第二近红外窗口
Baisong Chang1, Jie Chen1, Jiasheng Bao1
1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, Hubei 430070, China.
Chemical reviews
|November 22, 2023
概括
室温光 (RTP) 探针为改善生物医学成像提供了长寿命. 本综述探讨了从可见到近红外II (NIR-II) 波长发射的RTP探针的分子工程,以提高成像性能.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 材料科学 材料科学 材料科学
- 光物理学的光学物理学
背景情况:
- 光提供了比自流光更长的发光寿命,对生物医学应用有价值.
- 像灵敏度,分辨率和透深度这样的成像指标随着更长的波长而改善,特别是在第二次近红外 (NIR-II) 窗口 (1000-1700 nm) 中.
- 对光探测器的最佳开发策略,考虑到排放波长和长寿命,需要仔细考虑生物成像.
研究的目的:
- 审查用于室温光 (RTP) 探针的新兴分子工程方法.
- 讨论RTP开发背后的光物理机制.
- 为了突出 RTP 排放在可见到 NIR-II 窗口中的作用,用于生物应用.
主要方法:
- 对RTP探头开发的分子工程策略的审查.
- 对影响光特性的光物理机制的分析.
- 在不同光谱区域 (可见于NIR-II) 中评估RTP探头性能.
主要成果:
- 长寿命的探测器,即使有可见辐射,也可以可视化深层组织.
- 长波长光,结合长寿命,显著提高了时空分辨率,透深度和生物成像的灵敏度.
- 新兴的RTP探测器在可见到NIR-II波长中展示了各种生物成像任务的潜力.
结论:
- 分子工程为开发具有定制光物理性质的RTP探头提供了途径.
- 优化辐射波长和发光寿命对于推进生物成像能力至关重要.
- 对于未来的生物医学应用,RTP具有显著的前景,其开发和利用面临着持续的挑战和前景.
相关概念视频
Photoluminescence: Applications
406
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
406
Photoluminescence: Fluorescence and Phosphorescence
2.1K
Photoluminescence is a process where a molecule absorbs light energy and re-emits it in the form of light. This phenomenon occurs when a substance absorbs photons, promoting its electrons to higher energy level excited states, followed by a relaxation process in which the electrons return to their original ground state energy levels and emit light. Photoluminescence is widely observed in various materials, including semiconductors, and organic and inorganic compounds.
A pair of electrons in a...
A pair of electrons in a...
2.1K
Fluorescence and Phosphorescence: Instrumentation
617
Fluorometers and spectrofluorometers are two types of instruments used for measuring molecular fluorescence. These instruments differ in how they select excitation and emission wavelengths and the type of light sources they utilize. Fluorometers use absorption interference filters to choose excitation and emission wavelengths. The excitation source in a fluorometer is typically a low-pressure mercury vapor lamp that emits intense lines distributed throughout the ultraviolet and visible regions.
617
Variables Affecting Phosphorescence and Fluorescence
506
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
506

