了解葡萄皮糖类药物,甲状腺甲状腺激素水平和患者骨质疏松症之间的长期相互作用
11Department of Community Medicine, Parul University, PO Limda, Tal.Waghodia, District Vadodara, Gujarat, India.
Georgian medical news
|November 22, 2023
概括
长期使用葡萄糖皮质激素 (GC) 与骨质疏松症有关. 这项研究在患有骨质疏松症的GC用户中发现了较高的副甲状腺激素 (PTH) 水平,这表明PTH是骨问题的标志物.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 葡萄糖皮质醇 (GCs) 由于其抗炎性质而被广泛使用.
- 长期或高剂量的GC使用可能会导致不良反应,包括骨密度下降.
- 骨质疏松症 (OP) 是与GC治疗相关的重大健康问题.
研究的目的:
- 调查长期使用葡萄糖皮质激素和骨质疏松症之间的关系.
- 在GC诱导的骨质疏松症患者中评估甲状腺上腺激素 (PTH) 和 (Ca) 水平.
- 确定潜在的生物标志物来预测GC用户的骨矿物质异常.
主要方法:
- 对100名参与者进行了病例控制研究 (50名骨质疏松症患者,50名对照).
- 参与者根据年龄和性别进行了匹配.
- 甲状腺上腺激素 (PTH) 和 (Ca) 的血液水平被测量并在各组之间进行比较.
主要成果:
- 骨质疏松症患者与对照组相比,表现出明显更高的副甲状腺激素 (PTH) 水平.
- 在骨质疏松症患者组中, (Ca) 水平显著降低.
- 在PTH水平和骨矿化状况之间观察到正相关性.
结论:
- 高水平的PTH与长期使用葡萄糖皮质类药物的骨质疏松症有关.
- 在慢性GC治疗的患者中,PTH可以作为检测骨矿物质异常的预后标志物.
- 监测PTH可以帮助早期预测和管理GC诱导的骨并发症.
相关概念视频
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Skeleton and Calcium Homeostasis
4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K


