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长期COVID患者的疲劳
K Ivantsov1, V Lim1, I Kukes2
11I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.
Georgian medical news
|November 22, 2023
概括
长期COVID疲劳涉及异常的代谢特征,包括乳酸和二甲基氨酸水平升高. 适度的体力活动改善了患者的疲劳症状和临床结果.
科学领域:
- 代谢学 代谢学 代谢学
- 长期COVID研究研究
- 后病毒综合征 后病毒综合征
背景情况:
- 长期COVID,是SARS-CoV-2感染后的疾病,经常会出现持续的疲劳.
- 了解长期COVID疲劳的潜在病理生理学对于开发有效治疗方法至关重要.
研究的目的:
- 描述长期COVID相关的疲劳患者的代谢概况.
- 在体力活动干预期间观察代谢参数的动态变化.
主要方法:
- 对24名被诊断为"COVID-19后不确定的情况"的患者进行前性研究 (U09.9).
- 临床评估包括修改后的医学研究委员会 (MRC) 呼吸障碍尺度,6分钟步行测试 (6MWT),多维疲劳库存 (MFI) 尺度和巴特尔指数.
- 在基线和随访期间 (1日和14-18日) 确定了新陈代谢参数.
- 参与中度有氧活动的患者 (步行45分钟,每周3次).
主要成果:
- 观察到乳酸,烟酸,对称二甲基氨酸 (SDMA) 和不对称二甲基氨酸 (ADMA) 的水平升高.
- 在研究期间,酸水平正常化.
- 在体育活动后,MRC,MFI,6MWT和Barthel指数得分有显著的改善 (p<0.001).
- 发病后60天的代谢概况显示出复杂的异常.
结论:
- 长期COVID患者的代谢概况表现出一组复杂的异常.
- 这些代谢变化表明了致病基因药物治疗的潜在治疗点.
- 身体活动干预措施在改善长期COVID疲劳的临床症状和功能结果方面表现有希望.
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