创伤后压力障碍的药理学
T Tregub1, M Lytvynenko1, V Kukushkin2
11Odessa National Medical University, Ukraine.
Georgian medical news
|November 22, 2023
概括
目前的创伤后应激障碍药物治疗缺乏统一的方法. 选择性血清素再吸收抑制剂 (SSRI) 和血清素 - 上腺素再吸收抑制剂 (SNRIs) 是一线药物,但西对认知益处有希望.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 创伤后应激障碍 (PTSD) 药物治疗缺乏标准化的治疗指南.
- 现有的治疗方法,包括SSRI和SNRIs,具有局限性和副作用.
- 由于潜在的风险,使用二胺需要谨慎使用.
研究的目的:
- 评估目前用于PTSD的药物治疗策略.
- 综合证据证明在PTSD管理中有效使用药物.
- 确定新兴和有前途的治疗选择.
主要方法:
- 在PubMed,Ovid和EMBASE数据库 (2012-2022) 中进行全面的文献搜索.
- 关键词:"创伤后应激障碍"",治疗"",药物".
- 对14篇高度相关的文章进行内容分析,以制定建议.
主要成果:
- 关于最佳的PTSD药物治疗,目前还没有达成共识.
- 尽管有副作用,SSRI和SNRIs是第一线药物,FDA批准了塞特拉林,帕洛克塞丁和弗洛克塞丁.
- 伏尔托克塞丁对认知功能 (注意力,记忆,执行功能) 显示出潜在的益处.
- 阿尔法-1和阿尔法-2上受体对抗剂/对抗剂显示了一些治疗证据.
- 建议使用普拉佐辛和特拉佐治疗与PTSD相关的失眠.
结论:
- 创伤后应激障碍的药物治疗需要使用具有多模式作用的药物.
- 进一步的随机临床试验对于开发有效的PTSD治疗方法至关重要.
- 伏尔托克塞丁代表了创伤后应激障碍治疗的有希望的途径,特别是在认知缺陷方面.
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