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南美儿童心脏代谢风险因素:系统性审查和元分析
Carolyn M H Singleton1, Sumeer Brar1, Nicole Robertson1
1University of Kentucky College of Medicine, Lexington, Kentucky, United States of America.
PloS one
|November 22, 2023
概括
南美儿童面临着高水平的肥胖和脂质失调症. 标准化定义对于更好的诊断和研究至关重要,特别是对于土著人口来说.
科学领域:
- 儿科 儿科 儿科
- 公共卫生 公共卫生
- 心脏病学 心脏病学
背景情况:
- 心脏代谢风险因素 (禁食葡萄糖受损,腹部肥胖,高血压,脂质失调) 在儿童中越来越多地被发现.
- 这些因素聚集在一起,可以预测成人疾病负担.
- 关于南美儿童心脏代谢风险因素的数据有限.
研究的目的:
- 量化0-21岁南美儿童心脏代谢风险因素的患病率.
- 确定该地区关于这些风险因素的现有知识差距.
- 为公共卫生战略和未来的研究方向提供信息.
主要方法:
- 在PubMed,谷歌学者和LILACS (2000-2021) 的系统文献搜索.
- 包括来自10个南美国家的研究.
- 数据由两个独立审核员提取.
主要成果:
- 患病率:12.2%的肥胖,21.9%的腰围升高,3.0%的禁食葡萄糖受损,18.1%的高甘油三,29.6%的低HDL胆固醇,8.6%的高血压.
- 在不同研究中,对心脏代谢风险因素的定义存在显著差异.
- 农村环境和土著起源与较低的风险有关,而智利和厄瓜多尔对某些因素的患病率最高.
结论:
- 南美儿童患肥胖,超重和脂质不良的发病率很高.
- 建立关于儿科心脏代谢风险因素定义的国际共识对于准确的诊断至关重要.
- 未来的研究应该针对代表性不足的国家和土著人口.
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