幼儿疫苗反应的变化在幼儿中
Michael E Pichichero1, Lei Xu1, Eduardo Gonzalez1
1Center for Infectious Diseases and Immunology, Research Institute, Rochester General Hospital, Rochester, NewYork.
The Journal of infectious diseases
|November 22, 2023
概括
早期的细胞因子生物标志预测了儿童的疫苗反应. 低疫苗响应者 (LVRs) 显示T细胞记忆和抗原呈现细胞功能受损,与LVR相关的抗生素暴露.
科学领域:
- 儿科免疫学 儿科免疫学
- 疫苗学 疫苗学 疫苗学
- 传染病流行病学 传染病流行病学
背景情况:
- 幼儿疫苗反应的变异性尚未得到充分理解.
- 识别疫苗反应的早期预测因素对于公共卫生至关重要.
研究的目的:
- 为了识别预测婴儿免疫反应的生命早期生物特征.
- 调查抗生素暴露与疫苗反应之间的关系.
- 描述不同疫苗反应的儿童的免疫记忆和抗原呈现细胞 (APC) 功能.
主要方法:
- 在婴儿早期 (1-3周) 收集的鼻分泌物用于细胞因子/化学因子分析.
- 在1岁时采集的血液样本,以评估疫苗反应 (低,正常,高) 和免疫记忆.
- 在体外对抗原呈现细胞 (APC) 功能的评估.
主要成果:
- 婴儿早期的特定细胞因子/化学因子概况预测了低疫苗响应 (LVR) 状态.
- 抗生素暴露与LVR的发病率增加相关.
- LVR儿童表现出CD4+ T-辅助体记忆细胞反应降低和亚最佳APC功能.
结论:
- 早期的细胞因子生物签名可以预测孩子的疫苗反应.
- 婴儿时期使用抗生素与免疫反应受损有关.
- 低免疫反应的特点是T细胞记忆诱导和APC功能的缺陷.
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