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Updated: Jul 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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德格龙MD:利用进化和结构特征来解读蛋白质向降解,突变和对德格龙的药物反应

Haodong Xu1,2, Ruifeng Hu2,3,4, Zhongming Zhao2,5,6

  • 1Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Molecular biology and evolution
|November 22, 2023
PubMed
概括

DegronMD 识别了超过 18,000 个新的降解子,对于有针对性的蛋白质降解至关重要. 这个资源映射了影响蛋白质降解的突变,有助于癌症研究和药物发现.

关键词:
我们的数据库数据库数据库数据库.降级 degron 降级 降低 降低药物反应 药物反应进化分析是一种进化分析.机器学习是机器学习.蛋白质向性降解的向性降解无处不在的蛋白酶体系统

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