合成化三酸框架用于反歧视
Fatemeh Beyranvand1, Armaghan Khosravi2, Fatemeh Zabihi3
1Faculty of Science, Department of Chemistry, Lorestan University, 6815144316 Khorramabad, Iran.
ACS applied materials & interfaces
|November 22, 2023
概括
研究人员开发了金属驱动的聚合物,以创建用于enantiodiscrimination的 chiral triazine框架. 特定的金属催化剂指导了二维,形和花束结构的形成,影响了它们的特性和形识别能力.
科学领域:
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
- 奇拉化学 奇拉化学
背景情况:
- 共价有机框架 (COF) 通过分子层面的结构操纵提供可调节的特性.
- 嵌合式COF对于诸如反分离和不对称催化等应用至关重要.
- 开发有效的方法来构建有控制架构的性COF是必不可少的.
研究的目的:
- 报告一种新的金属驱动聚合法,用于合成合式三酸框架.
- 研究不同金属性指导剂 (PdCl2,ZnCl2,CuCl2) 对框架结构和特性的影响.
- 评估合成框架的反歧视能力.
主要方法:
- 氨酸和氨酸化物之间发生核性替代反应.
- 使用 PdCl2,ZnCl2 和 CuCl2 作为性指导剂来控制聚合.
- 使用诸如CD光谱学之类的技术,对产生的框架 (2D网络,卡力克,花束结构) 进行表征.
- 通过从纯净的反体和赛米混合物中加载L-histidine来评估反分离性能.
主要成果:
- PdCl2促进了具有较大的横向尺寸的二维三酶网络的形成.
- ZnCl2和CuCl2分别导致了非平面的和花束结构.
- 卡利克斯和花束结构呈现出明显的圆形二重化 (CD) 光谱.
- 卡利克斯和花束框架显示,从纯粹的反体中,L-histidine的吸收优于D-histidine.
- 与2D网络不同的是,Calix框架显示了从raceme混合物中显著吸收L-histidine.
结论:
- 金属驱动的聚合提供了一条通往具有多样性架构的性三酶框架的多功能途径.
- 选择金属性指导剂决定了所得到的框架结构及其CD特性.
- 卡利克斯类型的性 triazine 框架表现出有前途的 enantiodiscrimination 能力,从racemic 混合物的特定的enantiomers.
相关概念视频
Prochirality
3.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.8K
Chirality at Nitrogen, Phosphorus, and Sulfur
5.7K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
5.7K
Naming Enantiomers
20.4K
The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system...
20.4K
Stereoisomerism of Cyclic Compounds
8.9K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
8.9K
Racemic Mixtures and the Resolution of Enantiomers
18.4K
A racemic mixture, or racemate, is an equimolar mixture of enantiomers of a molecule that can be separated using their unique interaction with chiral molecules or media. Racemic mixtures are denoted by the (±)- prefix. This ‘optical rotation descriptor’ applies to the whole solution of a racemic mixture rather than a specific stereoisomer. Enantiomers typically have the same physical and chemical properties. Hence, they are not easily separable. However, enantiomers can exhibit...
18.4K
Molecules with Multiple Chiral Centers
11.7K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
11.7K


