免疫疗法及其时机在先进的基础细胞癌治疗中
Clio Dessinioti1, Alexander J Stratigos1
1Skin Cancer and Melanoma Unit, 1st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece.
Dermatology practical & conceptual
|November 22, 2023
概括
刺途径抑制剂 (HHI) 是先进的基底细胞癌 (BCC) 的第一线治疗方法,但 discontinuation 是常见的. 本综述探讨了转向免疫疗法,如塞米普利马布,作为晚期BCC患者的下一步可行的下一步.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期基底细胞癌 (BCC) 通常需要全身治疗,当手术或放射治疗不是治愈的选择.
- 刺途径抑制剂 (HHI),如vismodegib和sonidegib,已被批准为高级BCC的第一线疗法.
- 由于疗效,不良事件或患者选择,观察到高HHI中止率 (88-92%),需要使用替代治疗策略.
研究的目的:
- 审查高级基底细胞癌 (BCC) 患者的治疗决策,停止服用刺途径抑制剂 (HHI).
- 突出免疫疗法的作用,特别是抗PD-1剂塞米普利马布,作为后续治疗选择.
- 讨论在先进的BCC管理中支持抗PD-1药物的证据.
主要方法:
- 对临床试验数据和临床实践观察结果的审查,关于在晚期BCC中中止HHI.
- 分析抗PD-1药物的疗效和安全性 (例如,塞米普利马布) 作为二线单一疗法或组合疗法的分析.
- 探索免疫疗法作为高级BCC的新辅助治疗的潜力.
主要成果:
- 刺途径抑制剂 (HHI) 的停用率很高,患者在8-12个月后停止治疗.
- 停止HHI的原因包括瘤反应,不良事件和患者的偏好.
- 免疫疗法,特别是塞米普利马布,正在成为HHI失败或停止后的关键治疗选择.
结论:
- 转换为免疫疗法,如塞米普利马布,对于停止HHI的晚期BCC患者来说,这是一个关键的治疗考虑.
- 抗PD-1药物证明了作为二线全身治疗和组合疗法的有效性和安全性.
- 检查点免疫疗法代表了先进的基底细胞癌的新辅助治疗策略.
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