切换为tildrakizumab后的有效性和安全性:真实世界多中心意大利研究银病
Eugenia Veronica Di Brizzi1, Dario Buononato1, Pierfrancesco Benvenuto1
1Dermatology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Dermatology practical & conceptual
|November 22, 2023
概括
蒂尔德拉基祖马布有效地治疗中度至重度斑块性牛皮,患者之前的生物疗法失败. 这项现实研究显示,在48周内,皮肤清除显著,生活质量有所改善.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 蒂尔德拉基祖马布是一种被批准用于中度至重度慢性斑块性牛皮的素-23抑制剂.
- 它向IL-23的p19亚单元,这是牛皮病原发生的关键细胞因子.
研究的目的:
- 评估Tildrakizumab的实际有效性,安全性和存活率.
- 评估之前生物治疗失败的患者的中期结果 (48周).
主要方法:
- 追溯的,多中心的观察性研究.
- 包括患有中度至重度斑块性牛皮和先前生物衰竭的成年患者.
- 牛皮重度指数 (PASI),身体表面积 (BSA) 和皮肤病生活质量指数 (DLQI) 在基线,12周和48周被评估.
主要成果:
- 在12周和48周观察到PASI,BSA和DLQI的显著降低 (P < 0.001).
- 平均PASI从基线时的19.2降至48周后的0.6.
- 平均DLQI从基线时的18.2提高到48周后的显著较低得分.
结论:
- 在现实临床环境中,tildrakizumab在管理中度至重度斑块性牛皮方面表现出有效性.
- 该药物在以前治疗失败的患者中显示了持续的疗效和耐受性.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
146
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
146
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K


