在跨诊断神经发育队列中测试心理病理学的三重网络模型
Jonathan S Jones1, Alicja Monaghan1, Amelia Leyland-Craggs1
1MRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
NeuroImage. Clinical
|November 22, 2023
概括
改变的大脑网络连接,特别是涉及突出 (SN),中央执行 (CEN) 和默认模式网络 (DMN),与神经发育状况有关,如年轻人的过度活跃和注意力不集中.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 心理病理学 心理病理学
背景情况:
- 三重网络模型表明Salience (SN),中央执行 (CEN) 和默认模式网络 (DMN) 之间的异常连接是神经发育条件的基础.
- 这个模型需要在多样化,跨诊断的儿科群体中进行经验验证.
研究的目的:
- 在儿童的跨诊断样本中调查SN,CEN和DMN功能连接和神经发育障碍之间的关系.
- 检查网络连接和过度活跃/冲动和注意力不集中之间的维度关联.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于评估175名神经发育障碍儿童和60名对照儿童的功能连接.
- 父母报告的措施评估过度活跃/冲动和注意力不集中.
- 连接模式与行为措施相关分析,控制共变量.
主要成果:
- 在患有神经发育障碍的儿童中,多动/冲动与增加的SN-CEN-DMN连接性相关.
- 在比较儿童中,多动/冲动与降低的CEN-DMN连接性有关.
- 在不同的大脑分片和运动校正策略中,研究结果是稳定的.
结论:
- 三重网络连接模式区分超诊断性神经发育困难,其特征是过度活跃/冲动.
- 潜在的机制包括推迟网络成熟,执行控制受损,以及认知和情感系统之间的发展异步.
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