帕瑟诺利德通过调节AMPK/GSK3β(Ser9) /Nrf2信号通路来缓解认知功能障碍和神经毒性

Jinfeng Sun1, Liwei Li2, Li Xiong2

  • 1Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China; Zhejiang TCM Key Laboratory of Pharmacology and Translational Research of Natural Products, School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin 133002, China.

概括

帕氏化物 (PTN) 是一种天然化合物,在治疗阿尔茨海默病 (AD) 方面表现有前途. 它保护大脑细胞,改善小鼠的记忆力,可能比目前的治疗方法更有效.

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