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相关概念视频

Brain Imaging01:14

Brain Imaging

234
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
586

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相关实验视频

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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一个基于神经成像的精准医学框架用于抑郁症.

Yao Xiao1, Fay Y Womer2, Shuai Dong3

  • 1Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China.

Asian journal of psychiatry
|November 22, 2023
PubMed
概括

这项研究使用脑成像 (ALFF) 识别了两种抑郁症亚型,并通过针对性的重复性横磁刺激 (rTMS) 治疗它们,显示出显著的症状改善和正常化的脑活动.

关键词:
抑郁症 抑郁症 抑郁症机器学习 机器学习精准医学是一门精准的医学.休息状态的功能性MRI.通过骨磁刺激来进行磁性刺激.年轻人 年轻人 年轻人 年轻人 年轻人 年轻人

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 医疗成像医学成像

背景情况:

  • 目前的抑郁症诊断依赖于主观症状,导致异质性.
  • 客观的神经成像生物标志物对于精确的抑郁症亚型和治疗是必要的.

研究的目的:

  • 开发和验证一种基于神经成像的抑郁症亚型系统.
  • 实施针对这些亚型的精确重复性横磁性刺激 (rTMS) 策略.
  • 评估特定亚型rTMS的临床疗效.

主要方法:

  • 两阶段研究涉及神经成像 (ALFF) 和高斯混合模型用于抑郁症亚型.
  • 在238名患者和66名对照组中确定亚型特定的rTMS目标.
  • 在72名住院患有抑郁症的年轻人中,精确rTMS的临床应用,用MRI和临床评估.

主要成果:

  • 确定了两种亚型:原型抑郁和非典型抑郁,基于不同的ALFF模式.
  • 背中介前额叶皮质针对原型;尾皮质用于非典型的抑郁症.
  • 在rTMS后,正常化的ALFF和高的症状反应率 (90%原型,70.73%非典型).

结论:

  • 成功开发了一种使用神经生物标志物和向rTMS治疗抑郁症的精准医学框架.
  • 该框架表现出有希望的结果,为分类,治疗和评估创建了一个闭环.
  • 建议进行进一步的随机对照试验以证实研究结果.