单一和组合甲酸盐的暴露与成人生物衰老有关
Zhihao Xiao1, Qian Li1, Zhiqi Wang2
1School of Public Health, Nanjing Medical University, China.
Ecotoxicology and environmental safety
|November 22, 2023
概括
在个人护理产品中常见的酸盐暴露与加速的生物衰老有关. 这项研究发现,大多数甲酸盐代谢物增加了衰老标志物,突出显示甲酸盐是显著的衰老风险因素.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 老年学是指老年学的学科.
背景情况:
- 生活方式和遗传是已知的衰老因素.
- 在化品和个人护理产品中常见的酸盐对衰老的影响仍然不清楚.
研究的目的:
- 调查甲酸盐暴露与生物衰老之间的关联.
- 探索单个和组合的甲酸盐暴露对衰老标志物的影响.
主要方法:
- 利用了来自4711名国家健康和营养检查调查 (NHANES) 参与者的数据 (2005-2010).
- 使用Klemera-Doubal方法测量生物年龄加速 - - 生物年龄 (KDM-BA) 和表型年龄 (PhenoAge) 基于13个生物标志物.
- 采用多重线性回归,加权量子和 (WQS) 和通用添加模型 (GAM) 来分析尿甲酸代谢物和衰老标志物之间的关系.
主要成果:
- 大多数尿甲酸代谢物与加速的生物衰老相关,除了mono-(carboxynonyl).
- 结合甲酸盐暴露显示出混合效应,但增加了KDM-BA和PhenoAge的加速度.
- 确定MCPP,MEOHP和MBzP是加速生物衰老的主要贡献者.
结论:
- 暴露于甲酸盐与衰老过程有显著的关联.
- 单个甲酸盐暴露主要与衰老有关,而联合暴露具有混合的影响.
- 酸盐被确定为一个显著的风险因素,有助于加速衰老.
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