小便中的重金属和学龄前儿童的注意力缺陷/多动症症状:混合暴露分析
Ching-Chun Huang1, Shih-Chun Pan2, Wei-Shan Chin3
1Environmental and Occupational Medicine, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan; Environmental and Occupational Medicine, National Taiwan University Hospital Hsin-Chu Branch, HsinChu, Taiwan.
Ecotoxicology and environmental safety
|November 22, 2023
概括
同时接触多种重金属,包括和,与学龄前儿童的多动和注意力不集中有关. 这与单一金属暴露的影响形成鲜明对比,突出显示混合重金属污染的风险.
科学领域:
- 环境健康 环境健康
- 儿科神经发育 儿童神经发育
- 毒理学 毒理学 毒理学
背景情况:
- 已知重金属的神经毒性作用,但对联合暴露的研究有限.
- 幼儿园儿童容易受到影响心理社会发展的环境毒素的影响.
- 了解混合重金属暴露对于儿童健康风险评估至关重要.
研究的目的:
- 评估神经毒性金属混合暴露与学龄前儿童心理社会行为之间的关联.
- 调查重金属同时暴露的共同影响,超出单一污染物的影响.
- 为了识别导致不良行为结果的特定重金属.
主要方法:
- 通过分层抽样,从台湾幼儿园招募了977名学龄前儿童.
- 测量了,,,,,,和的尿度.
- 用强项和困难问卷 (SDQ) 和斯旺森,诺兰和佩勒姆四号 (SNAP-IV) 尺度评估的心理社会行为.
- 量子g计算分析了混合重金属效应,并对单个污染物进行了多次线性回归.
主要成果:
- 单金属模型显示,,和对SDQ子集的不利影响.
- 对六种重金属的联合暴露显著增加了多动/注意力缺失症状 (β = 0.46).
- 和被确定为对多动/不注意的联合影响的主要贡献者.
结论:
- 同时暴露在多种重金属中,比单次暴露在儿童中,对过度活动/注意力不集中的风险更大.
- 尿中的和对SNAP-IV子集产生有害影响,尽管联合分析没有显著的影响.
- 需要进一步的研究来证实与儿童群体混合重金属暴露相关的风险.
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