控制肠道微生物群中的阿拉比南利用的关键遗传因素减轻了便秘和便秘
Chengcheng Zhang1, Leilei Yu1, Chenchen Ma2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Cell host & microbe
|November 22, 2023
概括
在Bifidobacterium longum中的abfA基因集群对于改善功能性便秘 (FC) 是至关重要的,因为它可以使arabinan利用. 这一发现引导了针对肠道运动障碍的向益生菌疗法的开发.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 基因组学就是基因组学.
背景情况:
- 胃肠道运动障碍和肠道失调与功能性便秘 (FC) 有关.
- 益生菌的有效性,特别是对Bifidobacteria的有效性,是菌株特异性的,并受到遗传因素的影响.
- 在Bifidobacterium longum中的阿拉比南利用 (abfA) 基因集群正在研究其在治疗肠道疾病中的作用.
研究的目的:
- 确定Bifidobacterium longum中abfA基因集群对功能性便秘治疗疗效的影响.
- 探索微生物阿拉比南利用在改善胃肠机动性问题的作用.
- 建立基因组学导向的益生菌疗法的原则.
主要方法:
- 利用功能性便秘的小鼠模型来评估B. longum及其abfA突变的疗效.
- 进行了一项双盲,随机,安慰剂控制的临床试验,使用abfA集群携带的B. longum.
- 分析了人类群体的abfA集群丰富性,并在无菌小鼠中进行了微生物群移植实验.
主要成果:
- 具有完整的abfA集群的B. longum,但不是abfA突变体,在患有FC的小鼠中改善了胃肠道运输,依赖于饮食中的阿拉比南.
- 在其他共生细菌中发现了abfA基因,对小鼠FC.有类似的abfA依赖作用.
- 接受abfA集群携带B. longum的临床试验参与者显示,使用阿拉比南的细菌得到了丰富,有益代谢物增加,并改善了FC症状.
- 在人类群体中,abfA集群的丰富性预测了FC,而微生物群移植实验证实了其在改善肠道运动性方面的作用.
结论:
- 微生物abfA集群是改善功能性便秘的关键因素.
- 肠道细菌对阿拉比南的利用在调节胃肠动性方面发挥着重要作用.
- 这些发现为开发针对性,基因组学引导的益生菌干预治疗FC和相关肠道疾病提供了基础.
相关概念视频
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
221
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
221
Drugs for Treatment of Constipation-Predominant IBS
180
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
180
Irritable Bowel Syndrome I: Introduction
280
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
280
Factors Influencing Drug Absorption: Disease States and Pharmacology
534
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
534
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
126
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
126


