情绪不稳定和心血管疾病风险的遗传学:一个单变量和多变量门德尔随机化研究
Miao Chen1, Zhen Wang1, Hongfei Xu1
1Department of Cardiovascular Surgery, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Journal of affective disorders
|November 22, 2023
概括
对情绪不稳定的遗传责任增加了六种心血管疾病 (CVD) 的风险. 这项门德尔随机化研究强调情绪不稳定是心脏病的重要危险因素.
科学领域:
- 遗传学和心血管健康
- 心理健康和疾病病因 病因学
背景情况:
- 心血管疾病 (CVD) 是全球死亡率和残疾的主要原因.
- 新兴研究表明,精神健康和心血管疾病风险之间存在重要联系.
- 传统的风险因素不能完全解释心血管疾病的发展,促使研究其他因素,如情绪不稳定.
研究的目的:
- 调查情绪不稳定与各种心血管疾病 (CVD) 之间的潜在因果关系.
- 利用孟德尔随机化 (MR) 分析来探索情绪不稳定性和它们对心血管疾病风险的影响的遗传倾向.
主要方法:
- 采用62个与情绪不稳定相关的单核酸多态变量作为英国生物库的仪器变量.
- 利用了来自七种心血管疾病全基因组关联研究的摘要级数据.
- 应用随机效应逆变量加权方法,并使用各种MR方法进行敏感性分析以验证.
主要成果:
- 对情绪不稳定的遗传责任与六种心血管疾病的增加几率有显著的关联:深静脉血栓,肺栓塞,心力衰竭,动脉高血压,心肌梗塞和冠状动脉疾病.
- 情绪不稳定的遗传成分也与较高水平的HDL胆固醇,甘油三,体重指数,吸烟和抑郁症有关.
- 这些关联在多变量MR模型中与传统的心血管风险因素保持独立.
结论:
- 门德尔的随机化研究表明,基因因应对情绪不稳定和多种心血管疾病风险增加之间存在潜在的因果关系.
- 这一发现强调了在心血管疾病预防和管理策略中考虑心理健康,特别是情绪不稳定的重要性.
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