使用实验室数据对CKD-EPI 2021年肌素方程的评估:加拿大不列颠哥伦比亚省临床实验室实践变化的考虑
1Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver Coastal Health, Vancouver, BC, Canada.
Clinical biochemistry
|November 22, 2023
概括
新的CKD-EPI 2021方程显示,与2009年版本相比,11.86%的患者的估计球透率 (eGFR) 类别有所改善. 这一更新通过重新分类个体来影响临床实践.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 流行病学 流行病学
背景情况:
- 英国哥伦比亚省的实验室使用CKD-EPI 2009方程 (不包括种族) 进行eGFR报告.
- 采用新的CKD-EPI 2021方程式需要与现有的2009版本进行比较.
研究的目的:
- 为了比较2009年CKD-EPI (不包括种族) 和2021年CKD-EPI的估计膜过率 (eGFR) 的非种族方程.
- 评估CKD-EPI 2021方程对eGFR类别重新分类使用现实实验室数据的影响.
主要方法:
- 收集了温哥华总医院的血清/血肌和人口统计数据.
- 使用CKD-EPI 2009 (不包括种族) 和CKD-EPI 2021方程计算eGFR.
- 在整个队列中比较了eGFR分布和评估的类别重新分类.
主要成果:
- 分析包括58,763名患者;中位数eGFR与2021年方程相比,从85至90毫升/分钟/1.73平方米增加.
- 2021年CKD-EPI方程式重新分类了11.86%的患者,主要从G3a到G2的eGFR类别.
- 在脏群体中,从G5到G4发生了统计学上显著的重新分类.
结论:
- 2021年CKD-EPI方程式在大量患者队列中显示了向更高的eGFR类别的积极转变.
- 11.86%的个人经历了改进的eGFR分类,在个人和人口层面提供了临床见解.
- 这种数据驱动的比较支持各省采用CKD-EPI 2021方程.
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