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红细胞和血小板输血能否在支气管肺功能失调症中起病原作用?
Timothy M Bahr1, Gregory L Snow2, Thomas R Christensen3
1Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT; Department of Neonatology, Intermountain Health, Murray, UT.
The Journal of pediatrics
|November 22, 2023
概括
在早产婴儿的输血与支气管肺功能障碍症 (BPD) 有关. 根据指导方针减少输血率可能会降低BPD的发生率和严重程度.
科学领域:
- 新生儿医学 新生儿医学
- 儿科重症监护 儿科重症监护
- 呼吸系统医学 呼吸系统医学
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的一个重大并发症.
- 血液产品输血在BPD病变发生中的作用仍在调查中.
研究的目的:
- 研究红细胞或血小板输血与早产婴儿BPD的发展和严重程度之间的关联.
- 评估输血对BPD率的限制性指南的遵守对输血的影响.
主要方法:
- 多医院对29周或1000克以下的婴儿进行了回顾性研究.
- 对输血数据和BPD等级的分析,直到36周的月经后年龄.
- 敏感性分析以探索潜在的因果关系,并为指导方针的影响建模.
主要成果:
- 患有BPD的婴儿比没有患有BPD的婴儿接受的输血要多得多.
- 每次输血增加了2.27个因子 (P < .001) 的发展BPD的几率.
- 高比例的输血不符合严格的指导方针,建模表明,如果遵循指导方针,BPD率可能会降低.
结论:
- 输血与早产婴儿BPD的发病率和严重程度的增加有关.
- 遵守严格的输血指南可能会导致BPD率的显著降低.
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