一个II期研究高流量鼻腔管用于缓解晚期癌症患者呼吸障碍的研究
Eri Takase1, Hiroaki Akamatsu1, Shunsuke Teraoka1
1Internal Medicine III (E.T., H.A., S.T., K.N., M.T., T.K., K.F., K.S., E.M., T.S., R.S., D.F., A.H., N.T., Y.O., Y.K., M.N., N.Y.), Wakayama Medical University, Wakayama, Japan.
Journal of pain and symptom management
|November 22, 2023
概括
高流量鼻腔管 (HFNC) 为患有呼吸障碍的晚期癌症患者提供了息选择. 这项研究发现,HFNC为大约一半的患者提供了有意义的缓解,改善了他们的生活质量.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 呼吸系统医学 呼吸系统医学
- 在瘤学瘤学.
背景情况:
- 呼吸不良是晚期癌症患者的常见和令人痛苦的症状.
- 在息护理环境中,治疗呼吸障碍的治疗选择有限.
- 高流量鼻腔管 (HFNC) 已成为呼吸困难的潜在干预措施.
研究的目的:
- 评估HFNC在接受息治疗的晚期癌症患者中缓解中度至重度呼吸障碍的疗效和耐受性.
- 为了评估HFNC在五天治疗期间的有效性.
- 为了确定HFNC是否是一种可行的息治疗选择.
主要方法:
- 一项前性研究招募了住院的晚期癌症患者,患有呼吸障碍 (NRS≥3) 和低氧化症.
- 患者在呼吸单元中接受了HFNC五天.
- 主要终点是经过24小时修改的博格尺度的平均变化;次要终点包括随时间和可行性的变化.
主要成果:
- 分析了21名患者;中位生存时间为19天.
- 经过24小时修改的博格尺度的平均变化为1.4点,其中57%的人获得了1.0点的改善.
- 早期响应者 (在2小时内) 可能会持续24小时的呼吸障碍改善;11名患者完成了HFNC的全部五天.
结论:
- 在晚期癌症患者中,HFNC证明了作为呼吸障碍的息治疗的潜力.
- 虽然没有达到主要终点,但观察到的改善表明临床相关性.
- 在这种患者群体中,HFNC为症状管理提供了一个可行的选择.
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