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Updated: Jul 10, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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基于triazolo[4,5-d]pyrimidin-5-amines的ERK3抑制剂未能证明对脂肪细胞功能的选择性影响

Andrei Belykh1, Izabela Hawro1, Katarzyna Kolczyńska-Matysiak1

  • 1Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.

Archives of biochemistry and biophysics
|November 22, 2023
PubMed
概括

细胞外信号调节激酶3 (ERK3) 调节脂解,但测试的抑制剂显示非选择性作用. 这些化合物通过影响ERK3.3以外的多个点,影响代谢健康.

关键词:
脂肪细胞是一种脂肪细胞.在ERK3的ERK3抑制剂 抑制剂 抑制剂在MAPK6中,您可以使用MAPK6.代谢过程中的代谢.三醇[4,5-d]胺-5-胺氨基

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