元素注射在癌症中的互补和替代作用:一个总体审查
Jixin Chen1, Shuqi Chen2, Huiyan Luo3
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, PR China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Department of Oncology, Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, PR China.
素注射 (EI) 显示出作为补充性癌症治疗的潜力,可能在与常规疗法相结合时提高疗效和减少副作用. 需要进一步的研究来确认其益处,并探索其在免疫疗法和药物输送中的作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 之前的元分析 (MAs) 建议将元素注射 (EI) 作为补充癌症治疗方法.
- 矛盾的发现和未经分类的证据限制了先前研究的临床指导.
研究的目的:
- 系统地评估元素注射 (EI) 在癌症治疗中的有效性和安全性.
- 评估对EI现有的元分析的方法质量和证据确定性.
主要方法:
- 在2023年5月19日之前从8个数据库中检索的31个元分析 (MA) 进行了聚合分析.
- 评估了MAs的方法质量和聚合证据的确定性.
主要成果:
- 包括的MA表现出不良的方法质量,在异质性分析,偏见风险和文献选择方面存在弱点.
- 与常规治疗 (CT) 结合的Elemene注射 (EI) 可以提高疗效并减少各种癌症的不良反应.
- 仅EI就有潜力改善恶性溢出的客观反应率 (ORR),并减少膀癌复发的副作用.
- 由于临床试验偏见,证据确定性被评为中度至非常低.
结论:
- 素注射 (EI) 显示出作为一种可行的癌症治疗的希望,但需要更强大的试验.
- 在免疫疗法,药物输送以及癌症治疗中的预测因素中,EI具有发展潜力.
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