暴露于的普通鱼的肠道免疫和微生物多样性受损,暴露于
Md Alamgir Kabir1, Md Golam Rabbane2, Marco R Hernandez3
1School of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, PR China; Department of Fisheries, University of Dhaka, Dhaka 1000, Bangladesh.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
|November 22, 2023
概括
水中的高 (Cd) 含量会损害鱼的肠道,造成损伤和改变肠道细菌. 这项研究揭示了显著的肠道损伤和暴露的普通鱼微生物群落的转移.
科学领域:
- 环境毒理学环境毒理学
- 鱼类生物学 鱼类生物学
- 微生物组研究的研究.
背景情况:
- 水中 (Cd) 对水生生态系统构成重大威胁.
- 鱼的肠道是Cd积累和毒性的主要地点.
- 肠道免疫和微生物多样性对鱼类健康至关重要.
研究的目的:
- 研究环境相关的高度对普通鱼 (Cyprinus carpio) 的肠道免疫力和微生物多样性的影响.
- 了解鱼肠中毒性的机制.
主要方法:
- 常见的鱼在30天内暴露在不同度的 (0.4和1.6毫克/升) 中.
- 分析了肠道组织的组织病理变化,免疫参数 (lyszyme,AKP,ACP),氧化应激标志物 (CAT,T-AOC,MDA,H2O2) 和酶活性 (α-amylase,lipase).
- 用16S rRNA测序来评估肠道微生物群落.
主要成果:
- 暴露于导致Cd在肠道中的显著生物积累 (在1.6 mg/L时增加约100倍).
- 组织病理学变化包括状缩,杯状细胞增加,肌肉侵蚀和炎症.
- 诱导免疫抑制,氧化应激,并抑制了消化酶活性.
- 观察到肠道微生物群的显著变化,其中蓝色细菌增加,有益细菌减少,如Aeromonas和Cetobacterium.
结论:
- 水中的高度严重破坏了鱼类的肠道平衡和健康.
- 毒性影响肠道结构,免疫功能,氧化平衡和微生物社区结构.
- 这些发现凸显了污染对水生生物的有害影响.
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