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在从单细胞DNA测序数据的基因树上整合SNV和CNA

Liting Zhang1, Hank W Bass2, Jerome Irianto3

  • 1Department of Computer Science, Florida State University, Tallahassee, Florida 32306, USA.

Genome research
|November 22, 2023
PubMed
概括

SCsnvcna是一种新的计算工具,通过将单核酸变异 (SNV) 放置在从副本数异常 (CNA) 信号推断出来的基因组上,构建瘤进化树. 这种方法通过使用独立的细胞集来检测SNV和CNA来克服技术上的挑战,从而改善了家族遗传分析.

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