埃洛比希巴特改善了60岁以上慢性便秘患者的直肠感觉:一项随机的安慰剂控制研究
Noriaki Manabe1, Minami Umeyama2, Sonoko Ishizaki2
1Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Okayama, Japan n_manabe@med.kawasaki-m.ac.jp.
BMJ open gastroenterology
|November 22, 2023
概括
胆汁酸载体抑制剂Elobixibat在慢性便秘的老年人中降低了直肠感觉值. 这表明这种患者群体的潜在治疗益处.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高直肠感觉值 (RST) 与慢性便秘 (CC) 有关,特别是在老年患者中.
- 胆汁酸 (BAs) 影响健康个体的RST,这表明它在感官感知中发挥作用.
研究的目的:
- 研究BA载体抑制剂埃米格西巴对CC老年患者 (≥60岁) 的RST的影响.
- 评估epipixibat对直肠敏感性,排便欲望和便BA度的影响.
主要方法:
- 一项前性研究,将老年CC患者和健康个体的RST进行比较.
- 一个随机的,双盲,安慰剂对照试验,在老年CC患者中对epipixibat进行实验.
- 测量第一个恒定的感觉体积 (FCSV),排便欲望体积 (DDV),最大可容忍体积 (MTV),直肠合规性和便BA度,使用治疗前和治疗后的barostat方法.
主要成果:
- 虽然在统计学上不显著,但RST在CC患者中往往高于健康对照组.
- 与安慰剂相比,Elobixibat显著降低了FCSV值 (p=0.0018) 并倾向于降低DDV值 (p=0.0899).
- 埃洛比克西巴提升了便BA度,特别是二次BA度,并且在具有较长CC持续时间或先前治疗史的患者中更有效.
结论:
- 埃洛比克西巴特有效降低慢性便秘的老年人直肠感官值.
- 这些发现表明,epipixibat可能通过调节直肠敏感性,为患有CC的老年患者提供治疗益处.
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