基因型为导向的新方法用于优化氧化在中国SLE患者中给予氧化的剂量
Han Xie1,2,3, Xin Wen2, Yuchun Wang1,2
1School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China.
Lupus science & medicine
|November 22, 2023
概括
在中国SLE患者中,CYP2C8和CYP2D6的遗传变异会影响氧化 (HCQ) 的血水平. 基因型定型和监测HCQ水平可以优化系统性红斑狼 (SLE) 的治疗.
科学领域:
- 药物基因组学 药物基因组学
- 免疫学 免疫学 免疫学
- 临床药理学 临床药理学
背景情况:
- 氧化 (HCQ) 是系统性红斑狼 (SLE) 的基石疗法.
- 血液中HCQ度的个体间变化可能会影响治疗的有效性和安全性.
- 人们怀疑遗传因素有助于这种变异性.
研究的目的:
- 为了研究基因多态化对中国SLE患者血液HCQ度的影响.
- 为了建立最佳的HCQ血度范围,以实现个性化的患者护理.
- 确定与HCQ代谢和治疗反应相关的特定遗传标记.
主要方法:
- 分析了489名接受HCQ治疗的中国SLE患者队列.
- 测量HCQ及其代谢物 (DHCQ,DDCQ) 的血液度.
- 关键代谢酶 (CYP2C8,CYP2D6) 中的单核酸多态 (SNPs) 被基因型化.
主要成果:
- 一个最佳的HCQ血度值被确定为559.67 ng/mL.
- CYP2C8 (rs7910936) TC/CC基因型和CYP2D6*10 (rs1065852) GG基因型与更高的HCQ水平有关.
- 特定的基因型与在不同的每日剂量下达到最佳HCQ度相关.
结论:
- 对于中国SLE患者来说,最佳的HCQ血液水平可能在500-600 ng/mL之间.
- 在CYP2C8和CYP2D6中的遗传多态性显著影响HCQ的药理动力学.
- 建议进行基因型测试和治疗药物监测,以个性化HCQ剂量.
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