风险分层查用于早期检测癌
Sabrina H Rossi1, Hannah Harrison2, Juliet A Usher-Smith2
1Department of Surgery, University of Cambridge, Cambridge, UK.
概括
对癌的风险分层查可以通过专注于高风险个体来改善早期检测. 利用现有的肺癌风险模型可能为脏癌症查提供一种具有成本效益的方法.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 预防医学 预防医学
背景情况:
- 早期发现癌是优先事项,但低患病率阻碍了一般人群中成本有效的查.
- 风险分层查针对高风险人群,有可能提高成本效益,减少低风险人群的伤害.
研究的目的:
- 审查风险分层查癌的证据.
- 突出利益,风险和管理潜在的危害.
- 为了确定未来的研究需求.
主要方法:
- 对风险分层查癌查模型的现有证据的审查.
- 对表型和遗传风险因素的分析.
- 对肺癌和癌查组合模型的评估.
主要成果:
- 现型模型在识别癌高风险个体方面表现出合理的准确性.
- 目前的证据不支持将遗传数据纳入癌风险模型.
- 使用肺癌风险模型可以识别25%的癌患者,与特定的表型模型 (27%-33%) 相比.
- 风险分层脏癌查是公众所接受的.
结论:
- 风险分层查有望改善早期癌检测和成本效益.
- 利用现有肺癌基础设施的综合查方法需要进一步调查.
- 需要进一步的研究来优化风险模型和管理潜在的危害.
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