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心血管,代谢和神经血管疾病的跨学科研究平台 (PICMAN) 协议

Mayank Dalakoti^1,2,3, Melvin Khee Shing Leow^4,5, Chin Meng Khoo^6,4

¹Department of Cardiology, National University Heart Centre, Singapore, Singapore. mayank_dalakoti@nuhs.edu.sg.

Scientific reports

|November 22, 2023

概括

皮克曼项目研究了代谢灵活性.

科学领域:

心血管医学心血管医学
代谢健康代谢健康
神经血管疾病神经血管疾病

背景情况:

代谢失调是心血管疾病的早期前体,特别是在亚洲人群中.
代谢不灵活可能表明无声的,高风险的进展,导致胰岛素耐药性,糖尿病和心血管疾病.

研究的目的:

为了将代谢灵活性与心脏代谢健康指标相关联.
建立针对心血管疾病预防的代谢不灵活性进行干预试验的队列.

主要方法:

试点,前性,多民族队列研究 (PICMAN项目).
招募120名参与者 (21-72岁) 具有10年ASCVD风险≥5%,不包括已确定的糖尿病.
使用广泛的多系统表型,包括心脏,血管,新陈代谢,肝脏和神经血管评估,以及收集血液样本用于多omics和iPSC生成.

主要成果:

数据收集和分析正在进行中.
这项研究旨在量化代谢不灵活性及其与心脏代谢参数的关联.

结论:

预计这些发现将阐明代谢不灵活性与心血管疾病风险之间的联系.
这项研究将通过准代谢健康,为未来预防心血管疾病的干预提供信息.

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