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自发脑内出血后的疲劳:患病率和相关因素

Giuseppe Scopelliti^1,2, Costanza Rossi¹, Grégory Kuchcinski³

¹Department of Neurology, Inserm, U1172-LilNCog-Lille Neuroscience & Cognition, CHU-Lille, Univ. Lille, F-59000, Lille, France.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|November 22, 2023

概括

在脑内出血 (ICH) 后,疲劳是常见的和持久的. 抑郁症状和皮质缩与这种长期疲劳有关,这表明潜在的治疗目标.

科学领域:

神经学神经学
神经科学是一个神经科学.
临床医学临床医学

背景情况:

疲劳是中风幸存者的重要问题,但对脑内出血 (ICH) 幸存者的具体数据有限.
这项研究调查了自发性ICH幸存者的队列中疲劳的长期患病率和相关因素.

研究的目的:

评估脑内出血 (ICH) 幸存者的疲劳的长期患病率.
为了确定与ICH后疲劳相关的临床和神经成像因素.

主要方法:

一年内ICH幸存者的前性,观察性,单中心研究.
使用查尔德疲劳量表 (分数≥4) 评估疲劳.
评估神经,抑郁,焦虑症状,功能障碍,以及小血管疾病 (SVD) 的脑MRI标志物在ICH后的1,3,6年.

主要成果:

51%的ICH幸存者在1年后报告疲劳,在3年 (51%) 和6年 (40%) 的随访中持续存在.
抑郁症状的严重程度与1年的疲劳有显著的关联 (aOR 1.4;95% CI 1.2-1.6).
在基线严重的皮质缩增加了一年疲劳的风险 (aOR 2.5;95% CI 1.1-5.8).

结论:

在脑内出血 (ICH) 后,疲劳是频繁且持久的.
皮质缩,而不是其他脑SVD的MRI标志物,与疲劳有关.
疲劳和抑郁症状之间的关联是一个潜在的治疗目标.

关键词:

脑内出血脑内出血在中风后的疲劳疲劳.小血管疾病标志物小血管疾病标志物

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